screen 1?

or screen 2?

screen 1 has a flexi news and flexi side/navigation area, which fits in with the flexi sections below
screen 2 has a flexi news column, with a fixed width side/navigation area
the side/navigation area currently shows a members login and contact area, but would normally be some sort of navigation menu - like the couch pop out menu on the left
i usually have a fixed width navigation because its kind of a waste of space to make it any bigger than it needs to be, but i think it looks kinda odd when it doesn't line up with the sections below.
the two above are with a max width set, disable the max width and you can get;
screen 1.2

screen 2.2

this makes the navigation side far too wide on 1.2 , but at least everything lines up nice!
so what do you think, flexi/flexi or flexi/fixed?
does anyone use full width with responsive design? i don't see many sites that do ... i guess it gets a bit harder to read long lines of text when you're at 1920 wide, 1200 wide seems alright though

